发信人: citytiger (小老虎~在等小兔), 信区: Biology
标 题: Re: denatured protein是不是还有聚集体?
发信站: The unknown SPACE (Tue Oct 10 19:10:52 2000), 转信

there are at least 12 caspases rigt now, they are all cystein proteases,
cut after asp (D) thus the name caspases. they are homologous to CED-3.
they can be divided into different groups, seems caspase-1 (ICE interleukin -1
converting enzyme) and some othe caspases are not very important in apoptosis,
but may play a role in immune responce. the other caspases are important in
apoptosis. they can be further divided into several groups by their role in
apoptosis, caspase 8 and 9 are thought to be initiators which are the upstream
activated caspases caspase 8 (FLICE) is important in death recptor mediated
apoptosis (to some extent caspase 10), while caspse 9 is important in stress
induced apoptosis. there are also caspases functions as amplifier and
executioner, one of the mostly studied is caspase 3, it can be activatied by
both caspase 8 and caspase 9. It has been shown it have important role in DNA
fragmentation. there are also caspase independent apoptosis pathways, such as
calpain ( I don't know how calpain induce apoptosis.
【 在 bioyy (豌豆园里的长工) 的大作中提到: 】
: Genetics, genetics will work for you!!!
: BTW who know the so-many caspase, 1 -- ?? (8?)
: which is protease, which is which :)
: and with CED?
: 【 在 yanan (花自飘零水自流) 的大作中提到: 】
: : protease?
: : I like protease.
: : what protease r u working ah?


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