发信人: netbuggie (中原一点虫), 信区: Biology
标 题: Re: questions about the latest version of human genome
发信站: The unknown SPACE (Thu Feb 15 17:07:53 2001), 站内信件

my understanding, for the 1st one, alternative splicing of a specific mRNA
will result in a totally different polypeptide. meanwhile, selection of
start codon will lead to differnt translated protein of a spliced mRNA.
it could be developmental-specific or tissue-specific. i guess it makes
the cell not overburdened with too much information. and it helps to explain
why there are quite less genes than we have expected, yet the network
produces such a complex organism in the world. the second question could
not be seriously addressed until we have compared the already annotated
"genes" with all sources of EST that we have derived from mRNA. all the
current algorithms have problem predicting TRUE genes. so it means that
we may still underestimate the genes in the genome.








【 在 bigbans (smile) 的大作中提到: 】
1.one gene can direct the synthesis of many proteins?

2.Based on a combination of computer data and human
analysis, there is some evidence that the genome may contain
another 12,731 or so genes, but it is too early to know for
sure.----from Celera site.
What does this mean?We didn't discover the complete
human genome?



--


--
※ 来源:．The unknown SPACE bbs.mit.edu．[FROM: 146.186.29.16]