发信人: Marble (小石头哥哥), 信区: Biology
标 题: Re: Anybody know this about Translation Initiation
发信站: The unknown SPACE (Fri Jun 21 17:10:24 2002), 站内信件

in the case of a couple of start codons, the context arround
is important to determine the initiation site. and the most
famous one is found by Kozak. basically, leaky scanning means
that ribosome scans the mRNA and bypasses the first start codon
it meets and initiates from a downstream one. some virus proteins
utilizes this mechanism for translation initiation.
shunting means "jumping". in adenovirus and hepatitis virus,
some genes use such ribosome shunting mechanism for translation
initiation. the principle is that the 40S ribosomal subunit
scans along the 5' UTR and then skips the 5' UTR that has
complicated 2nd structure for more efficient translation of
the gene.
for more detail, refer to Translational control of gene expression
Sonenberg, Hershey, and Mathews.

【 在 zzzzh (happy) 的大作中提到: 】
: What the difference between "Leaky scanning" and "Shunting model"?
: Thanks!


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