发信人: Marble (小石头哥哥), 信区: Biology
标 题: Mouse vs. Human
发信站: The unknown SPACE (Tue Jul 23 15:06:14 2002), 站内信件

why mouse? mouse models have been used to understand the functions
of the orthologous human genes extensively. clinical investigations
of genes that are related to various diseases have been facilitated
using transgenic mice, such as studies on cystic fibrosis,
myotony dystrophy, obesity, diabetes mellitus. the recent publication
on Science 296:1661, "a comparison of whole-genome shotgun-
derived mouse chromosome 16 and the human genome", has highlighen
the homology shared between these two species, which diverged
150 to 200 million years ago. of the 731 predicted genes on Mmu16,
509 could find orthologs on corresponding regions of the human
genome. more striking finding is the conserved sytenic blocks
share b/w Mmu 16 and Hsa 21, 3, 8, 16. the study is important
to prediction of new genes, characterization of regulatory element,
analysis of exon usage, as well as understanding of the "original
synteny" in the commone ancestor for mammalians.

BTW, Celera has done most of the work. for people who are interested
on "bioinformatics", this may give you some idea about what the best
bioinfor-company is doing now, though the commercial aspect has not
shown off yet.

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※ 来源:．The unknown SPACE bbs.mit.edu．[FROM: 146.186.]