发信人: Todd (托德), 信区: Biology
标 题: Viagra Deaths Explained By New Understanding Of Platelet Clumping
发信站: The unknown SPACE (Wed Jan 22 10:49:17 2003) WWW-POST

Incidents of heart attack and stroke, some fatal, in a small number of men
taking the drug Viagra have remained a puzzle. After all, Viagra, commonly
prescribed for erectile dysfunction, was originally developed to prevent these
conditions -- not only by dilating blood vessels but also by stopping
platelets in the blood from clumping.

In fact, the drug does just the opposite, according to researchers at the
University of Illinois at Chicago College of Medicine. They found that Viagra,
by elevating levels of a compound in cells called cyclic guanosine
monophosphate, or cGMP, actually encourages platelets to aggregate.

The study, published in the Jan. 10 issue of the scientific journal Cell,
amends 20 years of scientific claims that cGMP acts to prevent platelet
aggregation.

While platelet aggregation helps minimize the loss of blood when injury
occurs, it can also lead to clotting that blocks a blood vessel -- a
life-threatening condition called thrombosis that can cause heart attack and
stroke.


I happened to know the 1st, 2nd, and the senior authors in person. All of them
are from the same lab in China. Last night I talked to the 1st author. They
submitted their manuscript to nature back in 2000. It was rejected instantly.
Then to science, and it was rejected instantly too. They thought it might be
because that the results were too wild. So they had to try Cell and it took
them more than TWO years for the paper to get finally published on cell.
Unbelievable!

Another example that you don't have to be in a NIU lab to publish a NIU paper.
However you gotta have some luck and work very hard!




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※ 来源:．The unknown SPACE bbs.mit.edu．[FROM: 129.59.]