发信人: aubrey (黄山路), 信区: Biology
标 题: The SARS Genome - sciencemag
发信站: The unknown SPACE (Thu May 1 21:20:30 2003) WWW-POST

Published online May 1, 2003: http://www.sciencemag.org/feature/data/sars/


Characterization of a Novel Coronavirus Associated with Severe Acute
Respiratory Syndrome

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association
with cases of severe acute respiratory syndrome (SARS). The sequence of the
complete genome of SARS-CoV was determined, and the initial characterization
of the viral genome is presented in this report. The genome of SARS-CoV is
29,727 nucleotides in length, has 11 open reading frames, and the genome
organization is similar to that of other coronaviruses. Phylogenetic analyses
and sequence comparisons showed that SARS-CoV is not closely related to any of
the previously characterized coronaviruses.


The Genome Sequence of the SARS-Associated Coronavirus

We sequenced the 29,751-base genome of the severe acute respiratory syndrome
(SARS)-associated coronavirus known as the Tor2 isolate. The genome sequence
reveals that this coronavirus is only moderately related to other known
coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E.
Phylogenetic analysis of the predicted viral proteins indicates that the virus
does not closely resemble any of the three previously known groups of
coronaviruses. The genome sequence will aid in the diagnosis of SARS virus
infection in humans and potential animal hosts (using PCR and immunological
tests), in the development of antivirals (including neutralizing antibodies),
and in the identification of putative epitopes for vaccine development.


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