发信人: doggiebear (doggiebear), 信区: Biology
标 题: SBIG: Channels - 4
发信站: Unknown Space - 未名空间 (Fri Oct 17 00:11:03 2003) WWW-POST


Finally, Mackinon reveals two configuration of the potassium channel at high
and low potassium concentration. This actually corresponds to the native
configuration of the channel when it is closed or open.

Sorry I cannot find a free figure for this arguement.

One lesson is, how little conformation changes actually take place! Just some
side chain rotations. but it produces two different configuration. This let us
speculate how the Na/K ATPase might work. We know it has different
configurations, with different affinity to Na and K. Maybe this is similar to
our channel. Maybe it also have a channel like structure and with two or
multiple configurations. maybe ATP binding, hydrolysis, release ADP. binding
and release of Na and K are the key events triggering configuration
transition.

The beauty of his finding is here. Small physical changes lead to big
biological change.






--
I will vote a democrat even he is a dog.
Liberalism is something to be proud of!
※ 修改:·doggiebear 於 Oct 17 00:11:03 修改本文·[FROM: 208.180.]
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