发信人: doggiebear (doggiebear), 信区: Biology
标 题: SBIG: Aquaporin, the water channel - 1
发信站: Unknown Space - 未名空间 (Sat Oct 18 01:51:16 2003) WWW-POST

Yesterday, we mostly discussed the ion channels, though I talked a
little bit about water channel - aquaporin.
Let's look at this man.

http://www.the-scientist.com/images/yr2000/jun26/agre.jpg

Dr. peter Agre, the winner of this year's nobel price. What is his major
contribution? This man discovered the water channels, a class of protein named
as aquaporin, in 1980's.
The following table is the distribution and function of aquaporins in
human body.



****************************************************************************
Class Tissue Distribution Function

Aquaporin-0 Eye: lens fiber cells Fluid balance within the lens

Aquaporin-1 Red blood cells Osmotic protection
Kidney: proximal tubule Concentration of urine
Eye: ciliary epithelium Production of aqueous humor

Brain: choriod plexus cerebrospinal fluid
Lung: alveolar epithelial cells Alveolar hydration

Aquaporin-2 Kidney: collecting ducts Mediates antidiuretic
hormone activity

Aquaporin-3 Kidney: collecting ducts Reabsorbtion of water
Trachea: epithelial cells Secretion of water

Aquaporin-4 Kidney: collecting ducts Reabsorbtion of water
Brain: ependymal cells CSF fluid balance
Brain: hypothalamus Osmosensing function?
Lung: bronchial epithelium Bronchial fluid secretion


Aquaporin-5 Salivary glands Production of saliva
Lacrimal glands Production of tears

Aquaporin-6 Kidney ?

Aquaporin-7 Testis and sperm ?

Aquaporin-8 Testis, pancreas, liver, others ?

Aquaporin-9 Leukocytes ?
***************************************************************************

The figure below shows how the reabsorption of water back to blood is achieved
by the combination of aquaporin-2 and 3.









--
I will vote a democrat even he is a dog.
Liberalism is something to be proud of!
※ 修改:·doggiebear 於 Oct 18 01:51:16 修改本文·[FROM: 208.180.]
※ 来源:．Unknown Space - 未名空间 mitbbs.com．[FROM: 208.180.]