发信人: doggiebear (doggiebear), 信区: Biology
标 题: SBIG: Aquaporin, the water channel - 2
发信站: Unknown Space - 未名空间 (Fri Oct 17 23:27:17 2003) WWW-POST

Aquaporin is related to some diseases.

- Mutations in the aquaporin-2 gene cause hereditary nephrogenic diabetes
insipidus in humans.

- Mice homozygous for inactivating mutations in the aquaporin-0 gene develop
congenital cataracts. I don't know whether similar situation exists in human.

- Some people have been identified with severe or total deficiency in
aquaporin-1. Interestingly, they appear clinically unaffected, but have not
been examined under conditions of water deprivation. Mice with targeted
deletions in aquaporin-1 also appear normal and healthy unless they are fluid
restricted, in which case they become severely hyperosmolar.

Also, aquaporins can be drug targets. For example, since they are involved in
edema (accumulation of water) formation in important tissues,like brain or
lung, inhibitors blocking those channels may help allievate problems resulting
from water accumulation.

Actually some one already did aquaporin-4 knockout mice and find that mice is
pretty resistant to brain edema.


--
I will vote a democrat even he is a dog.
Liberalism is something to be proud of!
※ 修改:·doggiebear 於 Oct 17 23:27:17 修改本文·[FROM: 208.180.]
※ 来源:．Unknown Space - 未名空间 mitbbs.com．[FROM: 208.180.]