发信人: vanLoon (房龙), 信区: Biology
标 题: Re: 1st paper --random journal club
发信站: Unknown Space - 未名空间 (Sun Oct 19 17:49:39 2003), 转信

SNAREs can be grouped into t-SNARE (target) and v-SNARE (vesicle), or Q-SNARE
and R-SNARE based on sequence. 4 families have been found: syntaxin, SNAP-25-1,
SNAP-25-2 (Q type), and synaptobrevin (R type).

SNARE complex during membrane fusion is actually a 4 helical bundle, 2 from each
membrane location in the ratio of 3Q : 1R.

Besides this, the subunit c of the V0 sector of V-type ATPase, also called
proteolipid, is also shown to facilitate homotypic fusion in yeast, which was
published in Nature 2 years ago.

【 在 doggiebear (doggiebear) 的大作中提到: 】
: See this fiugre.
: the membrane fusion event.
: Before fusion:
: http://www-staff.psychiatry.cam.ac.uk/~dew22/supervisions/answers/vesicle1.jpg
: Start form complex:
: http://www-staff.psychiatry.cam.ac.uk/~dew22/supervisions/answers/vesicle2.jpg
: Ca and more tight binding:
: http://www-staff.psychiatry.cam.ac.uk/~dew22/supervisions/answers/vesicle3.jpg
: Fusion:
: http://www-staff.psychiatry.cam.ac.uk/~dew22/supervisions/answers/vesicle4.jpg
: Seperate the complex (recycle):
: http://www-staff.psychiatry.cam.ac.uk/~dew22/supervisions/answers/vesicle5.jpg
: Now I know the function of NSF is to recycle the SNARE SNAP complex. And NO
: inhibit its activity so inhibit the membrane fusion event. Cool!


--

恐怖是所有不宽容的起因。无论迫害的方法和形式是什么，它的原因都来自恐惧，它的集
中表现可以从树起断头台的人和把木柴扔向火葬柴堆的人的极端痛苦的表情中看得一清二
楚。我们一旦认清了这个事实，马上就有了解决这个问题的方法。人们在没有恐怖笼罩的
时候，是很倾向于正直和正义的。到现在为止，人们很少有机会实践这两个美德。

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