发信人: happyzhb (~手指疼~), 信区: Biology
标 题: Journal club this week
发信站: Unknown Space - 未名空间 (Wed Nov 19 09:06:05 2003) WWW-POST

Science. 2003 May 16;300(5622):1152-5.
Distinct cohesin complexes organize meiotic chromosome domains.

Kitajima TS, Yokobayashi S, Yamamoto M, Watanabe Y.

Department of Biophysics and Biochemistry, Graduate School of Science,
University of Tokyo, Tokyo 113-0033, Japan.

Meiotic cohesin complexes at centromeres behave differently from those along
chromosome arms, but the basis for these differences has remained elusive. The
fission yeast cohesin molecule Rec8 largely replaces its mitotic counterpart,
Rad21/Scc1, along the entire chromosome during meiosis. Here we show that Rec8
complexes along chromosome arms contain Rec11, whereas those in the vicinity
of centromeres have a different partner subunit, Psc3. The arm associated
Rec8-Rec11 complexes are critical for meiotic recombination. The Rec8-Psc3
complexes comprise two different types of assemblies. First, pericentromeric
Rec8-Psc3 complexes depend on histone methylation-directed heterochromatin for
their localization and are required for cohesion during meiosis II. Second,
central core Rec8-Psc3 complexes form independently of heterochromatin and are
presumably required for establishing monopolar attachment at meiosis I. These
findings define distinct modes of assembly and functions for cohesin complexes
at different regions along chromosomes.

Comment in:
Science. 2003 May 16;300(5622):1101-2.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids
=12750522&dopt=Abstract

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