发信人: wowotou (wowotou), 信区: Biology
标 题: Re: a bioinformatics question
发信站: Unknown Space - 未名空间 (Tue Jun 8 16:07:45 2004) WWW-POST

Agree. Currently, only homolgy modeling makes sense to biologists. The
state-of-the-art ab initio and fold recognition prediction methods are still
unable to reliablly predict even the correct fold (don't even think about the
full-atom, high resolution model which is very important for function
analysis). The problem here is how much you trust the predicted model before
you can go on to the next step for function analysis.

【 在 Rizhard (快乐的狗) 的大作中提到: 】
: in casp 5, nobody can do better than 4 Angstrom, also, it is not
: fully automated. Also, it doesn't work for proteins larger than 150
: residues. So, I would argue, this problem is unsolved. Maybe in CASP 6,
: some group could make some good predictions better than 1.0 Anstrom
: for some small alpha proteins, but generally, this method is far
: from mature...
: 【 在 lyms (davido) 的大作中提到: 】
: : Yes, it can be done.
: : Using method called Ab initio or ‘Novel’ Fold Recognition. The
hypothesis is
: : that the native structure of a protein corresponds to the minimum of its
free
: : energy.
: : 【 在 Rizhard (快乐的狗) 的大作中提到: 】
: : : ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
: : : Nobody can do this, there isn't any reliable method can do protein
structure
: : : prediction without using structure homologs.
: : database.
: : lot
:
:



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※ 修改:·wowotou 於 Jun 8 16:07:45 修改本文·[FROM: 199.184.]
※ 来源:．Unknown Space - 未名空间 mitbbs.com．[FROM: 199.184.]