发信人: jonzhang (清华MM的海鸥乔纳森), 信区: Biology
标 题: Re: progenitor cell and stem cell有什么
发信站: Unknown Space - 未名空间 (Thu Nov 11 10:07:48 2004) WWW-POST

Pluripotency and Totipoteny has similar meaning if not the same, i.e.
differentiation potential of all lineages but not SC of all different cell
types. But some ppl prefer to use Totipotency for ESC.

As I mentioned before, some of the adult stem cells are NOT true stem cells,
coz they only have limited self-renewal ability and differentiation potential.
So it's probably more approtiate to call them progenitor cells. Most time the
Sci would like to blow they find xxx type of stem cells, however, it's hard to
prove the pluripotency (all lineages, so many!!!) if self-renewal is easier to
prove. Do you believe they really find SC? I dont believe it, but I'd like to
blow it as SC if I find one. Hehe. To make thing more complicated, cell fusion
has been found in claimed self-renewal of SC.

I dont believe some SC are more committed than progenitro cells, coz
conceptally, PC is more committed than SC. It is suggested to refer to certain
tissue type or organ when we talk about the progenitor cells, such as mammary
gland progenitor/stem cells which were found by Max Wicha group.

【 在 mfelegans (celegans) 的大作中提到: 】
: ?I was a little confused and want myself understand clearly. When we say
Stem
: cells, it does not nessary means Embronic stem cells, which is pluripotency
or
: totipotencey, it can also mean stem cells of different cell lines. If I
: remember correctly, so far, scientists have collected like 74 (?) cell types
: stem cells. Some of those stem cells are more committed than progenitor
cells
: ??
: 【 在 jonzhang (清华MM的海鸥乔纳森) 的大作中提到: 】
: : No.
: :
: : Now, it's suggested to use somatic stem cells concept than adult stem
cells.
:
: :
: : As far as I know, progenitor cells are of less differentiation
: : potential(multipotency, just many progenies but not all), while stem cells
: are
: : of pluripotency (All of the progenies). So in this matter, PC is
considered
: : more committed, determined, or differentiated than SC. However, most time
: ppl
: : find adult stem cells which are really progenitor cells.
: :
: : One also needs to clarify precursor cells (or simply precursors), while
: : progenitor cells are defined. Mostly accepted concept is that precursors
are
: : committed cells to certain lineage of maybe one organ or one tissue type,
: : while progenitor cells can generate multiple lineages.
: :
: : Self-renewal potential is another important consideration, while PC is
: : compared with SC. See Clonist's comments before.
: :
: :
: : 【 在 lxyy (lxyy) 的大作中提到: 】
: : : is it adult stem cells
: : : 【 在 clonist (Epi) 的大作中提到: 】
: : : : generally speaking progenitor cells are dervied from stem cells. the
: fate
: : of
: : : : progenitor cells are more determined than stem cells and as a
: consequence
: : they
: : : : can only differetiated into a few cell types. while stem cells have
much
:
: : : : more potential to differentiate into various cells and organs. it's
all
: : about
: : : : potential.
: : : : 【 在 lxyy (lxyy) 的大作中提到: 】
: : :
: : :
: :
:
:

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