发信人: Garozzo (一缺三), 信区: Biology
标 题: Re: 高风险，高回报？关于膜蛋白结构研究的前景
发信站: Unknown Space - 未名空间 (Thu Feb 3 21:38:57 2005) WWW-POST

【 在 icestone (hahahaha) 的大作中提到: 】
For example, protein structure prediction. Although it is still not very
accurate, but when close homology exists, one can always get some useful
information by comparative modeling. You can also do fold
recognation/threading or even ab initio modeling, although they are generally
not so reliable.
As an potential area for research, it definitely deserves some attention.
Unlike soluble proteins, which have many different folds, membrane proteins
are more regular, such as trans-memberane helix and beta-barrels, which may
share some more common features due to the very similar membrane environment
they reside in. This will compensate the lack of known membrane protein
structures.

Other examples like protein interactions involving membrane proteins,
computational simulation of ion channels, just name a few.

: 【 在 Garozzo (一缺三) 的大作中提到: 】
: : I think computational biology may play important role in this area,
: for example? or in which aspects? :)
:
: : 【 在 icestone (hahahaha) 的大作中提到: 】
: : : I was told that the membrane proteins in Archaea is much easier to
: : crytallized
: : : than those in Eukaryote. MacKinnon crystalized the K+-channel in an
: Archaea,
: : i
: : : rememeber.
: : :
: : : 【 在 crystalmaker (风雨无阻) 的大作中提到: 】
: : : : 大家有做膜蛋白结构的吗？谈谈体会如何？
: : : :
: : :
: :
: :
:


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