发信人: mdrosophila (ranger), 信区: Biology
标 题: Re: Re: Recommand methods to prove DNA hairpin structure, t
发信站: BBS 未名空间站 (Mon Jun 5 16:52:02 2006)

I know no case that a hairpin from a newly emerged RNA strand can regulate,
either inhibit or promote, the transcription. Therefore, the mechanism of
stimulatry role by the hypothetical hairpin is not clear to me. As I know and
also pointe out by other people in this board, the classical rep repressor and
many other repressors inhibit the transcription by binding to a palindromic
DNA sequence upstream from the promoter region of a transcribed gene. Also, a
transactivation-responsive region (TAR) in the positive RNA strand of HIV
virus can stimulate the transciption at least in part by enhancing the
transcription elongation by recruiting TAR-binding protein TAT, which in turn
contacts an essential elongation factor P-TEFb of the polymerese II complex.
【 在 harrywfu (天南海北山东人) 的大作中提到: 】
: You said that the RNA hairpin might recruit a protein complex that stalls
the
: transcriptin machinery. Do you mean in the nucleus the newly formed RNA form

: haipin to bind proteins to inhibit transcription? It is reasonable for a RNA

: hairpin to bind proteins, but how to inhibit transcription?
: Single
: know
:
: recruit
: the



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