发信人: zzzzh (happy), 信区: Biology
标 题: Re: help: the infection mechanism of prion and how to prove it by expe
发信站: The unknown SPACE (Tue Apr 23 20:03:28 2002), 站内信件

Read following papers:

1.) Wickner RB. [URE3] as an altered URE2 protein - evidence for
a prion analog in Saccharomyces cerevisiae. Science.
264(5158):566-569,1994 Apr 22

This is *the* classic paper that got the whole show on the road
withrespect to prions in yeast.

2.) Edskes HK. Gray VT. Wickner RB. The [URE3] prion is an
aggregated form of Ure2p that can be cured by overexpression of
Ure2p fragments. Proceedings of the National Academy of Sciences of
the United States of America. 96(4):1498-1503, 1999 Feb 16.

3.) Schlumpberger M. Prusiner SB. Herskowitz I. Induction of
distinct [URE3] yeast prion strains. Molecular & Cellular Biology.
21(20):7035-7046, 2001 Oct.

These are two review articles that may be of help.

Wickner RB. Taylor KL. Edskes HK. Maddelein ML. Moriyama H.
RobertsBT. Prions in Saccharomyces and Podospora spp.: Protein-based
inheritance. Microbiology & Molecular Biology Reviews.
63(4):844-+,
1999 Dec.

Wickner RB. Edskes HK. Maddelein ML. Taylor KL. Moriyama H.
Prions
of yeast and fungi - Proteins as genetic material. Journal of
Biological Chemistry. 274(2):555-558, 1999 Jan 8.






If you do want to discuss the human prions, here are
tworeviews:

Pruisner, S.B. Prions. Proceedings of the National Academy of
Sciences of the United States of America. 95:13363-13383, Nov.
1998.

Weissmann, C. Molecular genetics of transmissible spongiform
encephalopathies. J. Biol. Chem. 274(1):3-6. 1999.


【 在 ccgg (wuwu) 的大作中提到: 】
: It is my qualify question.
: Thanks a lot


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※ 修改:．zzzzh 于 Apr 23 20:05:36 修改本文．[FROM: 152.3.248.165]
※ 来源:．The unknown SPACE bbs.mit.edu．[FROM: 152.3.248.165]